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HPE-Nutanix Partnership: Gen 12 Platforms & Edge-to-Cloud

Nutanix
06/24/2026
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to make sure that we have, frankly, a world-class experience when the products come together. Peter, welcome to Chicago. Welcome to .NEXT. It's so great to have you here. Yeah, thanks, man. It's a fantastic event, as always, right? We have been partnering for a long time across many, many generations of platforms, across both Intel and AMD, but HPE has a huge portfolio of storage, compute, networking. Tell us a little bit about where does Nutanix fit in the whole HPE ecosystem? You know, obviously, we just welcomed Juniper into the HPE family over the year since we were at .NEXT last. Yeah. And, you know, super excited about that. The AppStore integrations really make the whole situation, the whole story, the experience with Nutanix better. And then, you know, since we were here, you know, last time, you know, we announced at last .NEXT that we were going to migrate away from our traditional appliance approach to Nutanix and really move from our DX to our DL. Yes, that is one that has now actually completed. Right. And it's always interesting to see, you know, sometimes there are great consequences and sometimes those consequences are also like unexpectedly good. Yeah. And we are keeping up to date with the latest and greatest generations from HPE. We just introduced our portfolio in Gen 12. Yes. And it's out in the market. It is indeed. Have you been hearing some feedback from the customers? They really appreciate the performance gains, right? Whether it's on the Intel side, whether it's on the AMD side, you know, we do both. And, you know, we have had some really exciting announcements here today. Our HAI with AMD, the DL145, but also some of the more bread and butter like the 360, the 380, you know, those continue to basically roll out both on Intel and AMD. What they really care about is the flexibility of the platforms. They care about the manageability both through PRISM, but also through the deep integrations that we have between the Nutanix stack and the HPE stack. And then, you know, things like security, quantum safe, ILO, all the pieces that goes with that. That's something we're hearing a lot of really positive feedback on. So if you look ahead, what are some of the things that you think we can jointly go focus on and deliver for our customers? It falls into like three categories. The first one is experience. We continue to do an enormous amount of work between HPE R&D and Nutanix R&D to make sure that we have, frankly, a world-class experience when the product come together. So that's one. I think there's still more work to do. Our comm products are coming online inside of Nutanix. There's other pieces that comes with that that will further enhance the experience. Two, I really see the ability to go out and follow all the way from the edge to the cloud, whether it's private on-prem hybrid, whether it is colo, whether it's third-party hosted, whether it's out of cloud providers themselves. That and having the right portfolio mix for us to go out and provide that across standard HCI use cases, NCIC, AI at the edge, inferencing, and all the agentic stuff that we've been talking about. That's number two. And then I think an oft overlooked number three is this is very much an on-prem kind of infrastructure. Sovereignty, digital sovereignty, and all the things that comes with that, both in Europe through regulation, but also in Asia, simply due to sovereign governments. That's an area where we have very, very deep expertise. You have very deep expertise, and I'm really looking to take that conversation, that journey home.

TL;DR

  • HPE successfully completed migration from DX appliances to DL platforms for Nutanix, enabling faster adoption of latest hardware generations including Gen 12 Intel and AMD systems
  • New Gen 12 portfolio includes AI-optimized DL145 with AMD and general-purpose DL360/380 platforms, with customers reporting significant performance improvements and appreciating platform flexibility
  • Partnership roadmap focuses on three pillars: world-class integrated experience through joint R&D, comprehensive edge-to-cloud deployment options including AI inferencing, and digital sovereignty solutions for regulated markets

Summary

This conversation between Nutanix and HPE leadership at .NEXT 2026 highlights the evolution of their strategic partnership, particularly the successful migration from HPE's DX appliance approach to the more flexible DL platform architecture. The discussion covers the rollout of Gen 12 platforms across both Intel and AMD processors, emphasizing performance gains and deep integration between Nutanix's PRISM management and HPE's infrastructure stack including security features like Quantum-safe ILO. Looking forward, the partnership focuses on three key areas: enhancing the joint product experience through continued R&D collaboration, expanding edge-to-cloud capabilities across diverse deployment models (on-premises, colo, hybrid, and public cloud), and addressing digital sovereignty requirements particularly in European and Asian markets where regulatory and governmental mandates demand on-premises infrastructure expertise.

Chapters

0:00 - Partnership Overview & R&D Collaboration
0:26 - Nutanix in HPE Ecosystem
1:04 - DX to DL Migration Success
1:34 - Gen 12 Platform Rollout
2:28 - Future Roadmap & Strategic Focus

Key Quotes

0:00 "We continue to do an enormous amount of work between HPE R&D and Nutanix R&D to make sure that we have, frankly, a world-class experience when the products come together."
1:04 "We announced at last .NEXT that we were going to migrate away from our traditional appliance approach to Nutanix and really move from our DX to our DL."
3:39 "This is very much an on-prem kind of infrastructure. Sovereignty, digital sovereignty, and all the things that comes with that, both in Europe through regulation, but also in Asia, simply due to sovereign governments."

FAQ

What hardware platforms does the HPE-Nutanix partnership currently support?

The partnership supports HPE Gen 12 platforms across both Intel and AMD processors, including the AI-optimized DL145 with AMD and general-purpose systems like the DL360 and DL380. The migration from DX appliances to DL platforms enables faster adoption of new hardware generations.

How does the partnership address edge-to-cloud deployment requirements?

The joint solution spans the full infrastructure spectrum from edge to cloud, supporting on-premises private cloud, colocation facilities, third-party hosted environments, and public cloud providers. This includes standard HCI use cases, NCIC, AI inferencing at the edge, and agentic AI workloads.


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