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Securing Humans, AI Agents & Data in the Agentic Age

Mimecast
04/28/2026
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TL;DR

  • Cybersecurity is shifting focus to the "humans-agents-data triangle" as the unsecured top layer of the stack, with AI making mediocre attackers expert-level while creating new risks through autonomous agents and LLMs.
  • Mimecast evolved from email security to human risk management after recognizing that 80% of breaches originate from email attacks that succeed due to human behavior, not just technical vulnerabilities.
  • The biggest emerging attack surface is data exfiltration to unsanctioned AI, as employees create applications outside IT directories and move sensitive data into unauthorized systems, creating unprecedented sprawl and vulnerability.

Summary

In this NYSE Floor Talk interview from RSAC 2026, Mimecast CEO Marc van Zadelhoff outlines a fundamental shift in cybersecurity focus toward what he calls the "humans-agents-data triangle." After two decades of securing networks, endpoints, and applications, the industry is now confronting the unsecured top layer of the stack: human behavior and AI agents. Van Zadelhoff explains how AI is simultaneously empowering attackers—turning mediocre threats into expert-level adversaries—while creating productivity gains for defenders and introducing entirely new risk vectors through autonomous agents and LLMs. He describes Mimecast's evolution from email security to a comprehensive human risk management platform, emphasizing that 80% of breaches originate from email attacks that succeed due to human behavior. The company's approach combines visibility through user risk scoring, empowerment through awareness training, and control mechanisms that block risky behaviors across email, SaaS applications, browsers, and endpoints. Van Zadelhoff highlights data exfiltration to unsanctioned AI as the most critical emerging attack surface, noting that employees creating applications and moving data into unauthorized systems represent unprecedented sprawl and vulnerability in the agentic age.

Chapters

0:00 - Introduction and Market Landscape
0:29 - Rising Up the Security Stack
0:56 - AI's Impact on Attackers and Defenders
1:37 - The Humans-Agents-Data Triangle
2:27 - Expanding Attack Surface in Agentic Age
3:08 - Evolution to Human Risk Platform
4:20 - Managing Cyber Risk: Visibility, Empowerment, Control

Key Quotes

0:00 "Yeah, I think it all comes down to humans and agents on data. That's kind of the triangle that I'm seeing in the marketplace right now."
1:02 "I mean, listen, I think it's a better attacker, right? So a mediocre attacker becomes expert attacker."
2:06 "They have IDs, they have behavior, they are usually tethered to humans as much as we love talking about autonomous agents. Most of them, I say, are like dogs on a leash and the leash is still the human and they're prompting and telling them what to do."
3:21 "I think 80% of all breaches are caused by, are initiated by an email attack."

Categories:
  • » Data Protection » Backup & Recovery
  • » Data Protection
  • » Cybersecurity » Endpoint Security
  • » Cybersecurity » Compliance & GRC
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  • Email Security
  • Data Protection
  • AI & Machine Learning
  • Security Operations
  • Executive Briefing
  • Interview
  • Human Risk Management
  • AI Agents and Security
  • Data Exfiltration Prevention
  • Behavioral Risk Scoring
  • Insider Threat Detection
  • Security Awareness Training
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